Internal Medicine Journal Club

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1. How long to treat first and second episodes of idiopathic DVT

• PIER - Disease: Deep Vein Thrombosis
• UpToDate - 'Treatment of deep vien thrombosis'
• SUMSearch
  • Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Available from the National Guidelines Clearinghouse

2. Diagnosis of multiple sclerosis

• Hypertexts (online textbooks)
  • PIER - does not have a multiple sclerosis module
  • UpToDateŽ: 'Diagnosis of multiple sclerosis'
    • McDonald criteria
  • eMedicine - unreferenced content
• Search engine
  • SUMSearch
    1. National Collaborating Centre for Chronic Conditions. Multiple sclerosis. National clinical guideline for diagnosis and management in primary and secondary care. London (UK): National Institute for Clinical Excellence (NICE); 2004. Located at National Guidelines Clearinghouse
    2. Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis: A Consensus Statement. Arch Neurol. June, 2005;62(6): 865 PMID: 15956157 (note their search date)
    3. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event.
       N Engl J Med. 2003;349:139-45. PMID: 12853586 (on second page of SUMSearch). But Contradicted and initially stronger effects in highly cited clinical research. JAMA. 2005 Jul 13;294(2):218-28. PMID: 16014596
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