Internal Medicine Journal Club

University of Texas Health Science Center	--> School of Medicine -->	Department of Medicine

Appraising evidence
(levels of evidence & glossaries)

Applying evidence
(calculators & converters)

Finding evidence

List of questions

1. Thienopyridines vs aspirin+thienopyridines for CVA while on ASA

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2. Thienopyridines for NSTEMI, in addition to heparin, aspirin, intravenous IIb/IIIa inhibitors

PIER
UpToDate: Antiplatelet agents in unstable angina and acute non-ST elevation (non-Q wave) myocardial infarction
SUMSearch
- Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Antithrombotic therapy for coronary artery disease
  - " In these moderate- to high-risk patients who are also receiving clopidogrel, we recommend eptifibatide or tirofiban as additional initial treatment (Grade 2A)."
  - "Thus, while the effect of clopidogrel, administered in addition to aspirin and heparin, was consistent among the groups receiving and not receiving concomitant GP IIb/IIIa inhibitors, the incremental value of adding GP IIb/IIIa inhibitors to aspirin, heparin, and clopidogrel remains all uncertain."

3. Antibiotics for bronchitis/URI

PIER
UpToDate
SUMSearch
- Antibiotics for acute bronchitis. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD000245. PMID: 15494994

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