Internal Medicine Journal Club

University of Texas Health Science Center	--> School of Medicine -->	Department of Medicine

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Appraising evidence (levels of evidence & glossaries)

Applying evidence (calculators & converters)

Finding evidence

Keeping up

List of questions

Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease

• http://content.nejm.org/cgi/content/abstract/NEJMoa050461
• Points:
  • NNT

Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage

• http://content.nejm.org/cgi/content/full/352/8/777
• Points:
  • Continuous versus dichotomous variables. Exception is?
  • NNT
  • NNH

Does This Patient Have Influenza?

• http://jama.ama-assn.org/cgi/content/full/293/8/987
• Points
  • SPPIN and SNNOUT
    • Typical tests
      • Only help when confirm expectations
    • SPPIN and SNNOUT
      • Help when confirm
      • Also help when toss-up
    • When results are unexpected
      • Prevalence of 25%. Try test with sn and sp of both 98%
  • Likelihood ratios

Antibody Levels and Protection after Hepatitis B Vaccination: Results of a 15-Year Follow-up

• http://annals.org/cgi/content/full/142/5/333

Prevalence of BRCA1 and BRCA2 Mutations in Women Diagnosed With Ductal Carcinoma In Situ

• http://jama.ama-assn.org/cgi/content/full/293/8/964